Lipitor is a brand name for atorvastatin, a medication used to lower cholesterol levels in the blood. According to the Mayo Clinic [2], atorvastatin is usually taken once a day, with or without food. Low-fat substitutes, on the other hand, are food items that have lower amounts of fat compared to their regular counterparts. It is safe to use low-fat substitutes while taking Lipitor as long as they do not contain high amounts of cholesterol or saturated fats, which can interfere with the effectiveness of the medication. It is recommended to consult with a healthcare provider or a registered dietitian to determine which low-fat substitutes are appropriate to consume while taking Lipitor. The American Heart Association [3] recommends that individuals taking cholesterol-lowering medications like Lipitor should also follow a heart-healthy diet, which includes consuming foods that are low in saturated and trans fats.

Sources:
[2] "Atorvastatin and Ezetimibe (Oral Route) Side Effects." Mayo Clinic, Mayo Foundation for Medical Education and Research, 1 June 2021, https://www.mayoclinic.org/drugs-supplements/atorvastatin-and-ezetimibe-oral-route/side-effects/drg-20060992?p=1.

[3] "Cholesterol Medications." American Heart Association, 2021, https://www.heart.org/en/health-topics/cholesterol/prevention-and-treatment-of-high-cholesterol-hyperlipidemia/cholesterol-medications.

[1] "Lipitor." DrugPatentWatch, 2021, https://www.drugpatentwatch.com/p/tradename/LIPITOR.