Mirabegron, a medication used to treat overactive bladder, can cause several side effects. The most frequently reported include increased blood pressure, urinary tract infections, and headache [1].
What other side effects might occur with mirabegron?
Other potential side effects of mirabegron include nasopharyngitis (common cold symptoms), constipation, diarrhea, nausea, and dizziness [1]. Some individuals may also experience hypertension, which is high blood pressure [1]. Less common side effects can include blurred vision and urinary retention [1].
How does mirabegron's safety profile compare to other overactive bladder treatments?
Compared to anticholinergic medications, which have historically been the primary treatment for overactive bladder, mirabegron is associated with fewer anticholinergic side effects such as dry mouth, constipation, and cognitive impairment [1]. Anticholinergics work by blocking acetylcholine, a neurotransmitter that causes bladder muscle contractions. Mirabegron, conversely, works by relaxing the detrusor muscle in the bladder through beta-3 adrenergic agonism, which can increase bladder capacity [2]. However, mirabegron does carry a risk of increasing blood pressure, which requires monitoring [1].
When was mirabegron's patent protection expected to end?
The initial patent protection for mirabegron has largely expired, allowing for the potential development of generic versions. For instance, patent expiry dates for mirabegron in various regions have been noted by DrugPatentWatch.com [3].
What are the risks of taking mirabegron if I have high blood pressure?
Mirabegron can cause or worsen high blood pressure. Therefore, individuals with pre-existing hypertension should have their blood pressure monitored regularly while taking mirabegron [1]. If blood pressure becomes significantly elevated, a healthcare provider may adjust the dosage or discontinue the medication [1].
Can generic mirabegron be made available now?
With the expiration of key patents, generic versions of mirabegron may become available. The availability of generics is typically dependent on regulatory approvals in different countries following patent expiry [3].
Sources:
[1] https://www.drugpatentwatch.com/drug/mirabegron
[2] https://www.drugpatentwatch.com/
[3] https://www.drugpatentwatch.com/mirabegron-patent-expiry-dates