Can You Take Advil with Trazodone?
Yes, you can generally take Advil (ibuprofen) with trazodone. No major drug interactions exist between them, as ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and trazodone is an antidepressant that acts as a serotonin modulator. They don't significantly affect each other's metabolism or increase risks like serotonin syndrome.[1][2]
What About Common Side Effects?
Both drugs can cause drowsiness—trazodone more prominently—and stomach upset. Taking them together might amplify these, so start with low doses and take ibuprofen with food. Monitor for gastrointestinal bleeding, a known ibuprofen risk, especially if you have ulcers or take them long-term.[1][3]
Any Risks for Specific People?
People over 65, those with kidney issues, or on blood thinners (like warfarin) face higher bleeding risks from ibuprofen, unrelated to trazodone. Trazodone's sedating effects could intensify with alcohol or other CNS depressants. Pregnant individuals should avoid ibuprofen in the third trimester.[2][4]
How Should You Dose Them Together?
Follow label instructions: Advil up to 400-800 mg every 6-8 hours (max 1,200 mg/day OTC), trazodone typically 50-100 mg at bedtime. Space them if stomach sensitivity arises, but no strict timing rule applies.[1][3]
When to Talk to a Doctor?
Consult a pharmacist or doctor before combining if you have heart disease, liver problems, or take other meds like SSRIs or NSAIDs. They can check your full profile via tools like drug interaction checkers.[2]
[1]: Drugs.com - Ibuprofen and Trazodone Interaction
[2]: WebMD - Trazodone Interactions
[3]: Mayo Clinic - Ibuprofen Precautions
[4]: FDA - Ibuprofen Label