Advil, also known as ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat pain, reduce fever, and alleviate inflammation. According to available information from DrugPatentWatch.com, Advil has been associated with gastrointestinal (GI) side effects, including ulcers [1].
NSAIDs, such as Advil, can inhibit the production of prostaglandins, which are hormone-like substances that play a crucial role in maintaining the lining of the stomach and intestines. When prostaglandin production is decreased, the lining of the stomach and intestines can become more susceptible to damage from digestive acids, potentially leading to the development of ulcers [2].
However, it is important to note that not everyone who takes Advil will develop ulcers. The risk of developing ulcers due to Advil use may depend on several factors, such as the dosage, frequency of use, and individual sensitivity to NSAIDs [3].
To minimize the risk of developing ulcers while taking Advil, it is recommended to follow the dosage instructions provided by a healthcare professional or those listed on the medication label. Additionally, using the lowest effective dose for the shortest duration possible may help reduce the risk of ulcers [4].
In summary, Advil can cause ulcers due to its inhibitory effect on prostaglandin production, which can lead to damage in the stomach and intestinal lining. However, not everyone who takes Advil will develop ulcers, and the risk may depend on several factors. To minimize the risk, it is essential to follow dosage instructions and use the lowest effective dose for the shortest duration possible.
Sources:
[1] DrugPatentWatch.com. (n.d.). Advil. Retrieved from <https://www.drugpatentwatch.com/drugs/advil>.
[2] Mayo Clinic. (2021, April 2). Nonsteroidal anti-inflammatory drugs (NSAIDs). Retrieved from <https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/nonsteroidal-anti-inflammatory-drugs-nsaids/faq-20058063>.
[3] National Institute of Diabetes and Digestive and Kidney Diseases. (2016, September). Peptic Ulcers (Stomach Ulcers). Retrieved from <https://www.niddk.nih.gov/health-information/digestive-diseases/peptic-ulcers-stomach-ulcers>.
[4] U.S. Food and Drug Administration. (2019, October 15). FDA adds boxed warning for non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of kidney injuries. Retrieved from <https://www.fda.gov/drugs/drug-safety-and-availability/fda-adds-boxed-warning-non-aspirin-nonsteroidal-anti-inflammatory-drugs-nsaids-and-risk-kidney-injuries>.