Lower doses of methotrexate are often recommended for elderly patients due to age-related changes in metabolism and potential increased sensitivity to medications. According to a study published on PubMed, older patients may be more susceptible to methotrexate toxicity, suggesting that lower doses should be considered to minimize adverse effects [3]. This recommendation aligns with the information provided on Drug Patent Watch, which highlights the importance of appropriate dosing based on individual patient characteristics, including age [1]. Additionally, the study available on PMC further emphasizes the need for careful dose adjustments in elderly patients to optimize treatment outcomes and reduce the risk of side effects associated with methotrexate therapy [2].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/METHOTREXATE
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1741826/
[3] https://pubmed.ncbi.nlm.nih.gov/8972245/