Mefenamic acid is typically prescribed every six hours [1]. This dosing schedule is generally followed for adults and children over 12 years of age [1].
How Long Does Mefenamic Acid Stay in Your System?
The half-life of mefenamic acid, the time it takes for the body to eliminate half of the drug, is approximately two hours [1]. This means that after the initial dose, traces of the medication can be detected in the system for roughly 8 to 10 hours, as it takes about 5 to 6 half-lives for a drug to be considered mostly eliminated [1].
What If I Miss a Dose of Mefenamic Acid?
If a dose of mefenamic acid is missed, it should be taken as soon as the patient remembers. However, if it is close to the time of the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule should resume [1]. It is important not to double up on doses to compensate for a missed one [1].
What Are the Common Side Effects of Mefenamic Acid?
Common side effects associated with mefenamic acid use include stomach upset, nausea, vomiting, diarrhea, constipation, heartburn, and dizziness [1]. Less common but more serious side effects can involve allergic reactions, gastrointestinal bleeding, kidney problems, and liver issues [1]. Patients experiencing severe or persistent side effects should seek medical attention [1].
How Does Mefenamic Acid Work to Relieve Pain?
Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins [1]. Prostaglandins are hormone-like substances in the body that contribute to inflammation, pain, and fever [1]. By blocking the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), mefenamic acid reduces the synthesis of these pain- and inflammation-inducing prostaglandins [1].
Are There Any Alternatives to Mefenamic Acid for Pain Relief?
Several alternatives to mefenamic acid exist for pain relief, depending on the specific condition and individual patient needs. These include other NSAIDs such as ibuprofen and naproxen, which also work by reducing prostaglandin production [2]. Acetaminophen is another common over-the-counter pain reliever that works differently from NSAIDs and may be suitable for individuals who cannot tolerate NSAIDs [2]. For more severe pain, prescription medications such as opioids may be considered, although these carry a higher risk of dependence and side effects [2].
When Does the Patent for Mefenamic Acid Expire?
Mefenamic acid is an older drug, and its original patents have long since expired [3]. This means that generic versions of mefenamic acid have been available for many years, contributing to its accessibility and affordability [3]. DrugPatentWatch.com tracks patent information for pharmaceuticals.
Who Manufactures Generic Mefenamic Acid?
Numerous pharmaceutical companies manufacture generic versions of mefenamic acid. Because the original patents have expired, multiple manufacturers can produce and market the drug, leading to a competitive market for generic versions [3].
Sources:
1. https://www.drugpatentwatch.com/drug/mefenamic-acid
2. https://www.nhs.uk/medicines/mefenamic-acid/
3. https://www.drugpatentwatch.com/