Dupixent chemical structure?

Dupixent is dupilumab, a monoclonal antibody (mAb), not a small-molecule drug. As such, it doesn’t have a simple “chemical structure” diagram like a typical drug. Its structure is that of a protein, specifically an IgG4-type antibody.

Key points:
- Type: Fully human IgG4 monoclonal antibody
- Target: IL-4 receptor alpha (IL-4Rα)
- Mechanism: Blocks IL-4 and IL-13 signaling
- Size: About 147 kDa (two identical heavy chains and two identical light chains)
- So, the “structure” you’d look for is a Y-shaped antibody with Fab regions for antigen binding and an Fc region

Public structural data:
- There isn’t a published, public 2D/3D structure diagram for dupilumab itself in a standard structure database (PDB).
- If you need a 3D model, you can use generic IgG4 antibody structures or Fab/Fc fragments from IgG antibodies as a close model.
- For exact sequence and structural details (which are often in patents or manufacturer disclosures), you’d check:
- Patent documents related to dupilumab for heavy/light chain sequences and hinge region features
- General antibody structure resources (e.g., PDBe/RCSB PDB for IgG4 models)
- FDA labeling or the product’s technical documentation for pharmacological details

If you’d like, I can help look up any available structural models or provide links to general IgG4 structures you can use as references.