Lipitor is a medication that is commonly prescribed to reduce high levels of cholesterol in the blood. The active ingredient in Lipitor is atorvastatin, which works by inhibiting the enzyme that produces cholesterol in the liver [1].

According to a study published in the Journal of Clinical Lipidology, a high-fat diet can have a significant impact on the effectiveness of atorvastatin [2]. The study found that patients who followed a high-fat diet had lower levels of atorvastatin in their blood compared to those who followed a low-fat diet. This suggests that the dosage of Lipitor may need to be adjusted for patients who consume a high-fat diet.

Another study published in the journal Pharmacology Research investigated the effect of different diets on the pharmacokinetics of atorvastatin [3]. The study found that a high-fat diet decreased the absorption of atorvastatin, resulting in lower levels of the drug in the blood. The study suggests that patients who consume a high-fat diet may require a higher dose of atorvastatin to achieve the same therapeutic effect as those who follow a low-fat diet.

In conclusion, based on the studies cited, it appears that a high-fat diet can impact the effectiveness of atorvastatin and may require an adjustment in dosage. However, it is important to note that any changes to medication dosage should be made in consultation with a healthcare professional.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/21269482/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822686/