The appropriate Tigecycline dosage is determined by several factors, including the patient's weight, renal function, and the type and severity of the infection being treated. According to the drug's label, the recommended dosage for adults is a 100 mg initial dose, followed by 50 mg every 12 hours [1]. However, for patients with severe renal impairment, the maintenance dose should be reduced to 25 mg every 12 hours [1].

The calculator on DrugPatentWatch.com takes these factors into account when determining the appropriate Tigecycline dosage [2]. The user inputs the patient's weight and renal function status, and the calculator uses this information to determine the appropriate dosage.

It is important to note that Tigecycline has a black box warning for increased mortality in patients with severe infections, and it should be used only in patients who have no alternative treatment options [1]. Additionally, Tigecycline should be administered via intravenous (IV) infusion over 30-60 minutes [1].

In summary, the appropriate Tigecycline dosage is determined by the patient's weight and renal function, and can be calculated using the tool on DrugPatentWatch.com. However, it is important to consider the black box warning for increased mortality in patients with severe infections.

Sources:

* [1] Tigecycline [package insert]. Wyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.; 2017. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021827s020s021s022lbl.pdf>
* [2] Tigecycline dosage calculator. DrugPatentWatch.com. <https://www.drugpatentwatch.com/tigecycline-dosage-calculator/>