According to the sources provided, alcohol consumption can have a negative impact on the effectiveness of Lipitor (atorvastatin). Lipitor is a medication used to lower cholesterol levels in the blood, while alcohol is known to have negative effects on the liver. The liver is responsible for breaking down and eliminating Lipitor from the body, so if the liver is damaged by alcohol, it may not be able to metabolize the drug properly.

Verywell Health [2] states that drinking moderate amounts of alcohol (one drink per day for women and two drinks per day for men) may not have a significant impact on Lipitor's effectiveness. However, excessive alcohol consumption can lead to liver damage, which can impair the liver's ability to metabolize Lipitor.

Harvard Health Publishing [3] also notes that while moderate alcohol consumption may not have a significant effect on the effectiveness of Lipitor, heavy alcohol consumption can lead to liver damage and may cause the drug to accumulate in the body, potentially leading to adverse effects.

Drug Patent Watch [1] provides information on the composition of alcohol, which is ethanol. While ethanol is not known to interact directly with Lipitor, it can have an impact on liver function, which in turn can affect the metabolism of the drug.

In summary, while moderate alcohol consumption may not have a significant impact on the effectiveness of Lipitor, excessive alcohol consumption can lead to liver damage and may impair the liver's ability to metabolize the drug. Patients taking Lipitor should consult with their healthcare provider regarding alcohol consumption and any potential risks or interactions.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ALCOHOL
[2] https://www.verywellhealth.com/can-i-drink-wine-if-i-take-lipitor-1124044
[3] https://www.health.harvard.edu/newsletter_article/do-alcohol-and-statins-mix