Can Mavyret (glecaprevir/pibrentasvir) cause itching as a side effect?
Yes. Itching (pruritus) can occur with Mavyret. Pruritus is listed among the medication’s possible side effects [1].
What does itching from Mavyret feel like, and is it common?
Mavyret itching is typically described as generalized itch or localized itch, and it can range from mild to more bothersome. It is considered a known side effect, though the most common effects vary by patient [1].
When should itching be treated as an emergency?
Stop and get urgent medical care if itching comes with signs of a serious allergic reaction, such as trouble breathing, swelling of the face/lips/tongue, widespread hives, or severe rash. Those symptoms require immediate evaluation.
What can patients do if they’re itchy on Mavyret?
If itching is mild, patients often manage it with nonprescription measures and discuss symptomatic treatment with their clinician. If symptoms are moderate to severe, persistent, or accompanied by a rash, it’s important to contact the prescribing team promptly.
Could itching happen for reasons other than a drug reaction?
Yes. Liver disease and elevated bilirubin can also contribute to itching in some people. That’s one reason clinicians may assess timing (when symptoms started relative to starting Mavyret), the presence of a rash/hives, and other liver-related symptoms before attributing itching solely to the medication.
How to report side effects correctly
If you’re taking Mavyret and develop itching, note when it started, its severity, and whether you have a rash or hives. Share those details with your clinician, especially if it worsens during treatment.
Sources:
1. https://www.drugs.com/sfx/mavyret-side-effects.html