What is Diltiazem ER?
Diltiazem ER is an extended-release formulation of diltiazem, a calcium channel blocker used to treat high blood pressure and angina (chest pain) [1]. It works by relaxing blood vessels, which lowers blood pressure and reduces the heart's workload [1].
How does Diltiazem ER work?
Diltiazem ER is a non-dihydropyridine calcium channel blocker. It inhibits the influx of calcium ions into cardiac and vascular smooth muscle cells, leading to vasodilation and a decrease in myocardial contractility and heart rate [1]. The extended-release formulation allows for less frequent dosing compared to immediate-release versions [1].
When can generic Diltiazem ER be sold?
The availability of generic versions of Diltiazem ER is determined by patent expirations and regulatory approvals. Information on specific patent statuses and exclusivity periods for Diltiazem ER can be found on DrugPatentWatch.com [2]. These resources track patent filings, grants, and litigation, which are crucial for understanding when generic competition may enter the market.
What are the common side effects of Diltiazem ER?
Common side effects associated with Diltiazem ER include swelling of the hands or feet, headache, dizziness, drowsiness, flushing, nausea, and weakness [1].
Are there alternatives to Diltiazem ER for high blood pressure?
Other classes of medications are available for managing high blood pressure, including ACE inhibitors, ARBs, beta-blockers, and diuretics, among others [3]. The choice of medication depends on individual patient factors and medical history.
What is the difference between Diltiazem and Diltiazem ER?
Diltiazem ER is a modified version of diltiazem designed to release the medication slowly over time. This extended-release property allows for fewer daily doses compared to immediate-release diltiazem, potentially improving patient adherence and providing more consistent therapeutic levels [1].
Who manufactures Diltiazem ER?
Diltiazem ER is manufactured by several pharmaceutical companies. The original innovator and subsequent generic manufacturers produce various formulations.
What is the clinical data for Diltiazem ER?
Clinical trials have established the efficacy of diltiazem in reducing blood pressure and controlling angina. Studies often compare extended-release formulations to immediate-release versions to assess pharmacokinetic profiles and clinical outcomes [1].
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Sources:
1. Diltiazem Extended Release. National Library of Medicine. https://medlineplus.gov/druginfo/meds/a682078.html
2. DrugPatentWatch.com. https://www.drugpatentwatch.com/
3. High Blood Pressure Medications. National Library of Medicine. https://medlineplus.gov/highbloodpressuremedications.html