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How does probiotic use impact Lipitor's cholesterol lowering effect? Probiotics do not interfere with how atorvastatin, the active ingredient in Lipitor, lowers LDL cholesterol. Studies measuring LDL reductions in patients taking atorvastatin alone versus those taking it with probiotics show no significant difference in results. Why might someone take probiotics with Lipitor? Patients on statins like Lipitor sometimes take probiotics to offset digestive side effects such as constipation or loose stools. Some also use them for general gut health after antibiotic use.
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