What Is Neffy Used For?
Neffy (epinephrine nasal spray) treats Type I allergic emergencies, including anaphylaxis from food allergies, insect stings, or idiopathic causes. It delivers epinephrine intranasally to reverse severe symptoms like airway swelling, low blood pressure, and breathing difficulty.[1]
How Does Neffy Work?
Neffy uses a single-use nasal spray that propels 2 mg epinephrine into one nostril. Epinephrine acts fast—within minutes—to constrict blood vessels, relax airway muscles, and boost heart rate, countering anaphylaxis shock. It's needle-free, unlike EpiPen auto-injectors.[1][2]
Who Can Use Neffy?
Approved for adults and children weighing at least 30 kg (66 lbs). For kids 15-30 kg, half the dose is used by spraying into one nostril and discarding the device. Not for infants under 15 kg.[1]
Neffy vs. EpiPen: Key Differences
Neffy avoids needles, easing use in public or for needle-phobic patients. Both provide similar epinephrine doses (2 mg nasal equals about 0.3 mg injected), but Neffy works even if congested (spray bypasses blockage). EpiPen requires thigh injection and proper technique.[2][3]
| Feature | Neffy | EpiPen |
|---------|--------|--------|
| Delivery | Nasal spray | IM injection |
| Adult dose | 2 mg (one spray) | 0.3 mg |
| Pediatric (15-30 kg) | 1 mg (half dose) | 0.15 mg |
| Shelf life at room temp | 4 months after opening | 12-18 months |
| Cost (list price, approx.) | $3,250 for 2-pack | $700 for 2-pack |
Common Side Effects and Risks
Patients report nasal discomfort, throat irritation, headache, or nausea. Rare risks include heart palpitations or high blood pressure, especially with overuse. Always seek emergency care after use—Neffy is a bridge, not a cure.[1]
When Did Neffy Get Approved and Who's Making It?
FDA approved in August 2024. ARS Pharmaceuticals manufactures it after years of development to address EpiPen shortages and access issues.[1][4]
Cost and Availability
List price is about $3,250 for a two-pack, but copay cards drop it to $25 for insured patients. Available by prescription at pharmacies since fall 2024. Medicare covers it starting 2025.[3]
Sources
[1]: FDA Approval Label for Neffy
[2]: ARS Pharmaceuticals
[3]: GoodRx Neffy Pricing
[4]: NEFI Global News