Does Cymbalta (duloxetine) cause constipation?
Yes. Constipation is a known potential side effect of Cymbalta (duloxetine). Serotonin and norepinephrine changes in the nervous system can slow gut motility, which may lead to constipation in some people.
How common is constipation with Cymbalta?
Constipation is reported among Cymbalta’s adverse effects, though exact rates vary by study and dose. If you’re noticing symptoms after starting Cymbalta or after dose increases, the timing often points to the medication.
What to do if Cymbalta is causing constipation
If constipation starts after beginning Cymbalta, common first steps include:
- Drinking more fluids if you can
- Increasing dietary fiber (or using a fiber supplement if appropriate)
- Staying active and moving regularly
- Using an over-the-counter stool softener or laxative short-term if needed
If symptoms are persistent or severe, contact a clinician. Dose adjustments or a different treatment may be considered.
When constipation is more concerning
Get urgent medical care if you have constipation along with severe abdominal pain, vomiting, a swollen belly, blood in stool, or you cannot pass gas. These can signal complications that need prompt evaluation.
Can other meds or conditions make it worse?
Yes. Constipation risk can increase if you also take other medicines that slow bowel movements (some antihistamines, opioids, antacids with calcium/aluminum, and certain antidepressants), or if you already have constipation, low fluid intake, or low activity.
Does stopping Cymbalta help?
If Cymbalta is the cause, constipation usually improves after the medication is reduced or stopped, but you should not stop Cymbalta suddenly. Work with a prescriber on a safe taper plan if discontinuation is needed.
Sources: None provided.