Lacosamide, a medication used to treat partial-onset seizures, can be combined with other medications, but there are potential contraindications and interactions to be aware of. According to the prescribing information provided by the manufacturer, lacosamide should not be taken with strong CYP3A4 inhibitors, such as itraconazole, clarithromycin, and certain HIV protease inhibitors, as they can increase lacosamide blood concentrations, leading to potential adverse effects [1].

Additionally, lacosamide should be used with caution when combined with other medications that can cause central nervous system depression, such as benzodiazepines, barbiturates, and opioids, as this can increase the risk of sedation and respiratory depression [1].

It is important to note that the information provided here is not exhaustive, and other contraindications and interactions may exist. Therefore, it is essential to consult the prescribing information of both lacosamide and any other medication being considered for combination therapy and to consult with a healthcare provider before making any changes to medication regimens.

In summary, lacosamide can be combined with other medications, but there are potential contraindications and interactions to be aware of, including strong CYP3A4 inhibitors and central nervous system depressants. It is essential to consult the prescribing information and consult with a healthcare provider before making any changes to medication regimens.

Sources:

1. Vimpat (lacosamide) tablets, for oral use. Full Prescribing Information. UCB, Inc. December 2021. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/202333s053lbl.pdf>