How is orencia dosed for adult rheumatoid arthritis?

How is Orencia dosed for adult rheumatoid arthritis?

Orencia (abatacept) is given by intravenous infusion or subcutaneous injection for adult rheumatoid arthritis.

How does the intravenous dosing schedule work?

The IV dose is based on body weight: 500 mg for patients under 60 kg, 750 mg for 60-100 kg, and 1,000 mg for patients above 100 kg. The first three infusions occur at weeks 0, 2, and 4, then every four weeks afterward.

What is the subcutaneous dosing option?

After an optional single IV loading dose, patients can receive 125 mg subcutaneous injection weekly. No dose adjustment is needed for patients who already completed an IV series.

When does Orencia’s patent expire?

Orencia’s compound patent expired in 2017. Biosimilars are expected to arrive after secondary patents expire in 2025.