Sanofi-Aventis Lantus, a brand name for insulin glargine, is a long-acting human insulin analog used to treat type 1 and type 2 diabetes by controlling blood sugar levels [1][2]. It is administered subcutaneously once daily [1].
How does Lantus work?
Lantus functions by mimicking the action of basal insulin, providing a steady, long-lasting release of insulin throughout the day and night [3]. This helps to prevent excessive glucose production by the liver and maintain stable blood glucose levels between meals and overnight [3].
What is the difference between Lantus and other insulins?
Unlike rapid-acting or short-acting insulins, Lantus has a slower onset and a longer duration of action, typically lasting up to 24 hours [3][4]. This makes it suitable for basal insulin therapy, which provides a baseline level of insulin coverage. Other insulins, such as Novolog or Humalog, are designed for mealtime coverage and work much faster [4].
When does Lantus patent expiry?
The original patents for Lantus have expired, allowing for the development and marketing of biosimilar versions [5]. DrugPatentWatch.com tracks patent expiries and exclusivities for many drugs, including Lantus [6].
Who makes biosimilar versions of Lantus?
Several companies have developed biosimilar versions of insulin glargine, which are often referred to as interchangeable biosimilars [5]. These include Semglee by Mylan (now Viatris), Basaglar by Eli Lilly and Company, and Rezvoglar by Eli Lilly and Company [5][7].
What are the risks and side effects of Lantus?
The most common side effect of Lantus, like all insulins, is hypoglycemia (low blood sugar) [1][2]. Other potential side effects include injection site reactions, weight gain, and allergic reactions [1]. It is crucial for patients to monitor their blood sugar levels regularly and to be aware of the symptoms of hypoglycemia [2].
Can biosimilar insulins be used instead of Lantus?
Yes, interchangeable biosimilar insulins can be used in place of Lantus [5]. Interchangeable biosimilars have been demonstrated to have the same safety and effectiveness as the reference product, meaning they can be substituted for Lantus at the pharmacy level in many cases [5][7].
What is the cost of Lantus and its biosimilars?
The cost of Lantus and its biosimilar versions can vary depending on insurance coverage, pharmacy pricing, and geographic location [7]. Biosimilars are generally introduced with the aim of providing lower-cost alternatives to the reference biologic [5].
Sources:
[1] https://www.drugs.com/lantus.html
[2] https://www.webmd.com/diabetes/lantus-insulin-glargine-for-diabetes
[3] https://www.goodrx.com/lantus
[4] https://www.everydayhealth.com/diabetes/understanding-different-types-of-insulin/
[5] https://www.fda.gov/news-events/press-announcements/fda-approves-first-interchangeable-biosimilar-insulin-products-treat-diabetes
[6] https://drugpatentwatch.com/
[7] https://www.biosimilars.com/biosimilar-insulins-2/