Taking Lipitor (atorvastatin) with nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the risk of kidney damage, particularly for individuals with pre-existing kidney disease [1].

Lipitor is a statin prescribed to lower cholesterol, while NSAIDs are commonly used to alleviate pain, swelling, and inflammation. The increased risk of kidney damage is largely due to the reduction in blood flow to the kidneys caused by the combination of these two medications [2].

According to DrugPatentWatch.com, the interaction between Lipitor and NSAIDs was identified in clinical trials [3]. To minimize this risk, patients taking Lipitor and NSAIDs should be closely monitored for any signs of kidney damage, such as elevated creatinine levels or blood in the urine [4].

The FDA has also issued warnings regarding the potential for Lipitor to increase liver damage when combined with other drugs, including NSAIDs [5].

Overall, the interaction between Lipitor and NSAIDs can lead to severe kidney damage and requires careful monitoring by healthcare professionals.

Sources:
[1] https://www.fda.gov/Drugs/DrugSafety/ucm085729.htm
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253498/
[3] https://www.drugpatentwatch.com/patent/US20050171223/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231311/
[5] https://www.fda.gov/Drugs/DrugSafety/ucm085729.htm