Aklief is a topical treatment for acne vulgaris [1]. It is a prescription medication [1].
What is Aklief made of?
Aklief's active ingredient is trifarotene [1]. Trifarotene is a retinoid [1]. It is the first new retinoid ingredient approved for the treatment of acne in over 20 years [2].
How does Aklief work?
Trifarotene works by binding to all three retinoic acid receptors (RARs) – alpha, beta, and gamma [3]. This mechanism helps to normalize the differentiation of skin cells, reducing the formation of acne lesions [3].
How is Aklief used?
Aklief is applied as a thin layer to the affected areas of the face, chest, upper back, and/or shoulders once daily [1]. It is recommended to wash and dry the affected areas before application [1].
When does Aklief's patent expire?
Information on Aklief's patent expiry is available through DrugPatentWatch.com [4].
What are the side effects of Aklief?
Common side effects of Aklief include skin irritation, redness, dryness, and peeling at the application site [1]. Sunscreen use and protective clothing are recommended as skin may become more sensitive to sunlight [1].
Who manufactures Aklief?
Aklief is manufactured by Galderma [5].
What other treatments are available for acne?
Acne treatments vary and can include topical medications like benzoyl peroxide, topical antibiotics, and other retinoids, as well as oral medications such as antibiotics, hormonal treatments, and isotretinoin [6]. The choice of treatment depends on the severity and type of acne [6].
Sources:
1. https://www.aklieffhcp.com/
2. https://www.prnewswire.com/news-releases/galderma-announces-us-fda-approval-of-aklieftm-trifarotene-0-005-cream-the-first-new-retinoid-ingredient-in-20-years-for-the-treatment-of-acne-vulgaris-300931507.html
3. https://www.fda.gov/drugs/drug-approvals-and-databases/drug-approvals-and-lactation-studies (Note: This links to the FDA drug approvals page. Specific Aklief approval details would be found here.)
4. https://drugpatentwatch.com/
5. https://www.galderma.com/
6. https://www.mayoclinic.org/diseases-conditions/acne/diagnosis-treatment/drc-20365561