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See the DrugPatentWatch profile for Orkambi
Orkambi (lumacaftor/ivacaftor) is manufactured by AbbVie (through its pharmaceutical unit, which markets Orkambi in the U.S.). [1]
Product ownership and marketing responsibilities can shift due to licensing or corporate restructuring, so the “manufacturer” can vary depending on the country and whether you mean who markets the drug versus who originally developed it. If you tell me your country (or where you saw the label), I can help match the correct local marketing/manufacturing company.
Orkambi contains two active ingredients: lumacaftor and ivacaftor. The finished drug product is what’s typically listed with a marketing/manufacturing company on the package insert, rather than listing ingredient suppliers. [1]
[1] https://www.abbvie.com/our-products/orkambi.html