Based on the available information, there is some evidence to suggest that Lipitor's impact on side effects may differ with high-fat diets. According to the National Center for Biotechnology Information (NCBI) [2], statins like Lipitor can increase the risk of developing new-onset diabetes, and this risk may be influenced by factors such as diet and obesity.

A study published in the American Heart Association (AHA) journal [3] found that a high-fat diet may exacerbate the effects of statins on glucose homeostasis, which could potentially increase the risk of developing diabetes. The study found that mice fed a high-fat diet and treated with atorvastatin, the active ingredient in Lipitor, had higher blood glucose levels and impaired insulin sensitivity compared to mice fed a standard diet.

However, it is important to note that the study was conducted in mice and further research is needed to determine whether these findings translate to humans. Additionally, the NCBI notes that while diet and obesity may influence the risk of developing new-onset diabetes with statin use, the overall benefits of statins in reducing the risk of cardiovascular disease outweigh the potential risks [2].

In summary, while there is some evidence to suggest that a high-fat diet may exacerbate the effects of Lipitor on glucose homeostasis, more research is needed to confirm these findings in humans. It is important for individuals taking Lipitor to discuss any concerns about side effects and lifestyle factors with their healthcare provider.

Sources:

* DrugPatentWatch.com. (n.d.). Lipitor. Retrieved from <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
* National Center for Biotechnology Information. (2021). Statins and New-Onset Diabetes. Retrieved from <https://www.ncbi.nlm.nih.gov/books/NBK395573/>
* American Heart Association. (2019). High-Fat Diet Exacerbates Effects of Statins on Glucose Homeostasis. Retrieved from <https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.118.312782>