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Promacta generic?

See the DrugPatentWatch profile for Promacta

Promacta = Eltrombopag (Generic)

Item Information
Generic name Eltrombopag
Brand name Promacta (Pfizer)
Drug class Thrombopoietin‑receptor agonist (TPO‑RA)
Common indications • Thrombocytopenia in patients with aplastic anemia (AA)
• Thrombocytopenia associated with chronic hepatitis C (CHC)
• Myelodysplastic syndromes (MDS) with low platelet count (often in combination with lenalidomide)
Typical oral dosing • Aplastic anemia: 50 mg once daily (titrated to platelet goal, usually 50 mg–75 mg).
• Chronic hepatitis C: 25 mg once daily (titrated to platelet goal, usually 25 mg–50 mg).
• Myelodysplastic syndromes: 25 mg once daily (titrated).
Administration notes • Take on an empty stomach, 2 hours before or 4 hours after a meal.
• Avoid eating calcium‑rich foods, dairy, or calcium‑fortified products within 2 hours of dosing (they inhibit absorption).
• Do not take with antacids or iron supplements; wait at least 2 hours.
Key benefits • Stimulates megakaryocyte production → increases platelet count.
• Helps reduce need for platelet transfusions.
Common side‑effects • Nausea, vomiting, diarrhea, abdominal pain, headache.
• Elevated liver enzymes (monitor with LFTs every 4 weeks).
• Rare: thrombosis, splenomegaly, bone‑pain.
Warnings & precautions • Liver toxicity: ALT/AST ≥3× ULN or ≥5× ULN with symptoms. Stop therapy if severe.
• Thrombosis: monitor for signs of clotting, especially in patients with prior thrombotic events.
• Pregnancy: category C; use only if benefits outweigh risks.
• Drug interactions: avoid concomitant use of agents that affect CYP1A2 or CYP2C9; monitor for interactions with warfarin, dabigatran, etc.
Contraindications • Active hepatic disease (ALT > 2× ULN).
• Known hypersensitivity to eltrombopag.
Drug interactions • Iron, calcium, antacids → reduce absorption.
• Cytochrome P450: not major metabolism, but caution with inhibitors/inducers of CYP1A2 or CYP2C9.
• Anticoagulants: can increase thrombosis risk; monitor INR/bleeding.
Special populations • Renal impairment: not significantly cleared by kidneys; no dose adjustment required.
• Hepatic impairment: use with caution; monitor liver function.
How it works Eltrombopag binds to the thrombopoietin receptor (c‑MPL) on megakaryocyte progenitor cells, mimicking endogenous thrombopoietin. This promotes proliferation and differentiation into mature megakaryocytes, leading to increased platelet production.
Storage Store at 25 °C–30 °C (room temperature). Keep away from moisture and light.

How to get a generic

  • The FDA has approved several generic versions of eltrombopag (e.g., from companies like Bristol‑Myers Squibb, Sandoz, Teva).
  • Your pharmacy can fill a generic prescription for you.
  • The generic has the same active ingredient, potency, and safety profile as brand‑name Promacta—just a lower cost.

Quick Takeaway

  • Promacta is the brand name; the generic is eltrombopag.
  • It's a prescription drug used to raise platelet counts in specific blood disorders.
  • Follow dosing, timing, and monitoring instructions closely; discuss any new symptoms or medications with your provider.

If you’re considering or already taking this medication, keep a log of your platelet counts and liver enzymes, and check in with your doctor regularly. Always let them know if you’re pregnant, breastfeeding, or planning to become pregnant.



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