Lincomycin hydrochloride is an active pharmaceutical ingredient (API) used in the production of lincomycin, an antibiotic medication [1]. It belongs to the lincosamide class of antibiotics [2].
What is lincomycin hydrochloride used for?
Lincomycin hydrochloride is utilized to treat serious infections caused by susceptible anaerobic bacteria and certain susceptible aerobic Gram-positive bacteria [3]. These infections can include bone and joint infections, respiratory tract infections, and skin and soft tissue infections [3].
How does lincomycin hydrochloride work?
As an antibiotic, lincomycin hydrochloride works by inhibiting bacterial protein synthesis [2]. It binds to the 50S ribosomal subunit of susceptible bacteria, thereby preventing the formation of peptide bonds and halting bacterial growth [2].
What is the difference between lincomycin and clindamycin?
Clindamycin is a semi-synthetic derivative of lincomycin [4]. While both are lincosamide antibiotics, clindamycin generally exhibits broader activity against Gram-negative anaerobic bacteria and has better penetration into bone tissue [4].
When was lincomycin patented?
Information on specific patent dates for lincomycin hydrochloride is not readily available in the provided context. However, lincomycin was first isolated in the early 1960s [5]. For detailed patent information, resources such as DrugPatentWatch.com may offer a more comprehensive database [6].
Who manufactures lincomycin hydrochloride API?
Several pharmaceutical manufacturers produce lincomycin hydrochloride API. Companies specializing in API manufacturing globally offer this ingredient [7]. Specific suppliers can be identified through pharmaceutical ingredient directories.