Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. According to the sources provided, there is a potential for negative interaction between Lipitor and ibuprofen.

The first source, Drug Patent Watch [1], does not provide any information on the interaction between Lipitor and ibuprofen. However, the second source, Drugs.com [2], states that ibuprofen can increase the risk of side effects of Lipitor, such as liver damage and muscle problems. This is because ibuprofen can affect the way the body metabolizes Lipitor, leading to higher levels of the drug in the bloodstream. This can increase the risk of side effects associated with Lipitor.

The third source, Verywell Health [3], also confirms that ibuprofen can interact negatively with Lipitor. It advises that patients taking Lipitor should avoid taking high doses of ibuprofen or other NSAIDs without consulting their healthcare provider. The article also suggests that patients who experience muscle pain or weakness while taking Lipitor should avoid taking ibuprofen and other NSAIDs.

In conclusion, based on the sources provided, there is a potential for negative interaction between Lipitor and ibuprofen. Patients taking Lipitor should avoid taking high doses of ibuprofen or other NSAIDs without consulting their healthcare provider. If muscle pain or weakness occurs while taking Lipitor, patients should avoid taking ibuprofen and other NSAIDs and consult their healthcare provider.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.drugs.com/drug-interactions/ibuprofen-with-lipitor-1310-0-276-128.html
[3] https://www.verywellhealth.com/statin-side-effects-and-drug-interactions-698202