The generic name for Forteo is teriparatide [1].
When Will Forteo's Patent Expire?
The primary patents for Forteo and its active ingredient, teriparatide, have largely expired, paving the way for generic competition [2]. For example, U.S. Patent No. 5,795,865, related to teriparatide, expired in 2014 [2]. Other patents may have had varying expiration dates. Information on specific patent expirations and any ongoing litigation can be found on DrugPatentWatch.com [2].
Who Makes Generic Forteo?
Several pharmaceutical companies have developed and market generic versions of teriparatide. These include manufacturers such as Teva Pharmaceuticals, Mylan (now Viatris), and Apotex [1].
How Does Generic Teriparatide Compare to Brand-Name Forteo?
Generic teriparatide products are bioequivalent to brand-name Forteo. This means they contain the same active ingredient, teriparatide, in the same dosage form and strength, and are absorbed by the body at the same rate and to the same extent [3]. Regulatory agencies like the U.S. Food and Drug Administration (FDA) require generic drugs to meet the same quality and manufacturing standards as their brand-name counterparts [3].
What is Teriparatide Used For?
Teriparatide is a form of parathyroid hormone used to treat osteoporosis in postmenopausal women and men at high risk for fracture. It is also used to treat osteoporosis in men and women who have lost bone mass due to treatment with glucocorticoids or who have multiple risk factors for fracture. Teriparatide works by increasing bone formation [4].
What are the Side Effects of Teriparatide?
Common side effects of teriparatide include nausea, headache, dizziness, joint pain, and pain in the arms or legs [4]. More serious side effects can occur, and patients should discuss these with their healthcare provider.
What is the Cost of Generic Teriparatide?
Generic versions of medications are typically less expensive than their brand-name counterparts. The exact cost of generic teriparatide can vary depending on the manufacturer, pharmacy, insurance coverage, and geographic location [5].
What is the Mechanism of Action of Teriparatide?
Teriparatide is a recombinant form of human parathyroid hormone (PTH). It is an anabolic agent that stimulates bone formation by increasing osteoblast (bone-building cell) activity and mineral apposition rate [4]. It also increases calcium absorption in the intestines and reduces calcium excretion in the kidneys.
What are the Risks Associated with Teriparatide?
A boxed warning in the prescribing information for teriparatide notes an increased risk of osteosarcoma (a type of bone cancer) in rats. The relevance of this finding to humans is not known, but teriparatide should not be used in patients with a history of bone cancer or certain other bone conditions [4]. Other risks include hypercalcemia and potential cardiovascular effects [4].
Sources:
[1] https://www.drugpatentwatch.com/
[2] https://www.drugpatentwatch.com/
[3] https://www.fda.gov/drugs/generic-drugs
[4] https://www.nps.org.au/news/teriparatide-new-drug-for-osteoporosis
[5] https://www.goodrx.com/