How to use otrexup pen?

Preparing the Otrexup Pen

Otrexup is a single-use autoinjector pen delivering methotrexate for rheumatoid arthritis, psoriasis, or polyarticular juvenile idiopathic arthritis. Store it in the refrigerator at 36-46°F (2-8°C), but let it warm to room temperature for 30 minutes before use. Do not shake or expose to heat/light. Check the inspection window for clear, colorless solution without particles—if cloudy or expired, discard.[1][2]

Choosing and Cleaning the Injection Site

Inject subcutaneously (under the skin) once weekly. Rotate sites: abdomen (at least 2 inches from navel), upper outer thigh, or outer upper arm (with help). Avoid scarred, bruised, or tender areas. Clean site with alcohol swab and let dry.[1][2]

Step-by-Step Injection Instructions

1. Wash hands. Remove pen from carton; peel off yellow cap (do not twist).
   
2. Hold pen with gray cap pointing away at 90° angle to skin.
   
3. Press gray cap firmly against site until click (needle inserts).
   
4. Hold steady for 5 seconds (orange indicator moves to red line)—count aloud if needed.
   
5. Release pressure; lift pen straight up. Yellow cap locks over needle.
   
6. Check window: plunger should be at red line, confirming full dose.[1][2]
   
   Full dose injects automatically. Do not reuse or block air vents.
   
   

After the Injection

A small blood drop may appear—press with sterile gauze, do not rub. Dispose of pen in FDA-approved sharps container (not trash). If available, mail-back programs exist. Record dose date.[1][2]

What If Something Goes Wrong?

• No click or indicator doesn't move: Replace with new pen.
  
• Partial dose (plunger not at red): Call doctor—may need supplemental injection.
  
• Accidental injection (e.g., thigh instead of abdomen): Still counts as full dose; rotate next site.
  
• Allergic reaction or severe pain: Seek emergency help.[1][2]
  
  

Common Patient Questions

Patients often ask about pain: Pinch skin or ice beforehand; sting lasts seconds. No need to aspirate (pull back plunger). Folic acid supplements reduce side effects—discuss with doctor. Watch for infections, liver issues, or low blood counts; get regular blood tests.[1][2]

Official Resources and Training

Watch the patient video at otrexup.com or call 1-844-308-2837 for demo. Prescribers provide hands-on training. Full prescribing info confirms these steps.[1][2]

[1] - Otrexup Prescribing Information
[2] - Otrexup Instructions for Use