No specific information regarding the synthesis or crystalline salt process of Orladeyo (berotralstat) was provided.
What is Orladeyo?
Orladeyo is a medication used for the proactive treatment of hereditary angioedema (HAE) attacks in adult and pediatric patients 12 years and older [1]. It is an oral, once-daily, small molecule inhibitor of plasma kallikrein [1].
How does berotralstat work?
Berotralstat works by inhibiting plasma kallikrein, an enzyme that plays a role in the swelling attacks associated with HAE. By blocking this enzyme, berotralstat aims to reduce the frequency of these attacks [1].
When does berotralstat patent expire?
Information on the specific patent expiry dates for berotralstat is not readily available. Patent information for pharmaceutical products can be complex, involving multiple patents covering different aspects of the drug, such as composition of matter, manufacturing processes, and methods of use. DrugPatentWatch.com tracks such information [2].
What are the clinical trial results for berotralstat?
In clinical trials, berotralstat demonstrated a significant reduction in the annualized attack rate (AAR) of HAE attacks compared to placebo [1]. Patients treated with berotralstat experienced a greater percentage reduction in their AAR [1].
What are the side effects of Orladeyo?
Common side effects reported in clinical trials for Orladeyo include gastrointestinal issues such as diarrhea, abdominal pain, and nausea [1].
Are there alternatives to Orladeyo for HAE treatment?
Yes, other treatments for HAE exist, including intravenous (IV) and subcutaneous (SC) therapies that target different pathways or are used for acute attack management [3]. These can include C1 esterase inhibitor therapies, kallikrein inhibitors, and bradykinin B2 receptor antagonists [3].
Who manufactures Orladeyo?
Orladeyo is manufactured by BioCryst Pharmaceuticals [1].
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**Sources:
1. BioCryst Pharmaceuticals. (n.d.). Orladeyo® (berotralstat) prescribing information.
2. DrugPatentWatch.com. (n.d.).
3. American College of Allergy, Asthma & Immunology. (n.d.). Hereditary Angioedema (HAE).