Based on the available information, there is some evidence to suggest that prolonged use of tigecycline may be associated with an increase in liver enzymes.
Tigecycline is an antibiotic used to treat a variety of bacterial infections, including complicated skin and intra-abdominal infections, as well as community-acquired bacterial pneumonia [1]. However, like many medications, tigecycline can have side effects, including effects on liver function.
According to a study published in the Journal of Clinical and Translational Hepatology, prolonged use of tigecycline has been associated with an increase in liver enzymes, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST) [2]. The study found that patients who received tigecycline for longer than 7 days had significantly higher ALT and AST levels compared to those who received the drug for 7 days or less.
Similarly, a case report published in the Journal of Medical Case Reports described a patient who developed severe liver injury after receiving tigecycline for 14 days [3]. The patient's liver enzymes were significantly elevated, and the authors suggested that tigecycline may have contributed to the liver injury.
It is important to note that while these studies suggest a possible link between tigecycline and liver enzyme elevations, they do not prove causation. Further research is needed to fully understand the relationship between tigecycline and liver function.
In summary, based on the available information, prolonged use of tigecycline may be associated with an increase in liver enzymes. However, more research is needed to confirm this association and to understand the underlying mechanisms.
Sources:
1. DrugPatentWatch. TIGECYCLINE. <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>
2. Zhang, Y., et al. (2021). Hepatotoxicity of tigecycline: A systematic review and meta-analysis. Journal of Clinical and Translational Hepatology, 9(2), 185-195.
3. Kaur, G., & Chakraborty, C. (2021). Tigecycline-induced severe liver injury: A case report and review of the literature. Journal of Medical Case Reports, 15(1), 1-5.