Does Skyrizi List Fatigue as a Side Effect?
Skyrizi (risankizumab-rzaa), an IL-23 inhibitor for psoriasis, Crohn's disease, and ulcerative colitis, does not commonly cause fatigue. Clinical trial data and FDA labeling report fatigue in less than 1% of patients, classifying it as rare or not established as drug-related.[1][2]
What Side Effects Are Most Common with Skyrizi?
Patients most often experience upper respiratory infections (around 15-20%), headaches (5-10%), injection site reactions (3-5%), and fatigue-like symptoms such as feeling tired from infections rather than the drug itself. Serious risks include infections and rare hypersensitivity reactions.[1][3]
Why Might Someone Feel Fatigued on Skyrizi?
Fatigue reports could stem from underlying conditions like psoriasis or IBD, which cause tiredness independently. Infections—a known Skyrizi risk—may also contribute. Post-marketing data shows no strong causal link, but individual factors like concurrent medications or disease flares play a role.[2][4]
How Do Patients Describe Fatigue Experiences?
User reviews on platforms like Drugs.com note occasional tiredness (average rating impact: low), often transient and tied to starting treatment. Clinical studies (e.g., IMMvent trials) tracked no significant fatigue increase versus placebo.[3][5]
When to Talk to a Doctor About Fatigue on Skyrizi?
Contact a provider if fatigue persists beyond 2-4 weeks, worsens, or accompanies fever, weight loss, or anemia—these signal possible infection or IBD activity. Routine monitoring includes blood tests for inflammation markers.[1][2]
How Does Skyrizi's Side Effect Profile Compare to Similar Drugs?
| Drug | Common Fatigue Rate | Key Notes |
|------|----------------------|-----------|
| Skyrizi | <1% | Lowest among IL-23s; infection-driven. |
| Tremfya (guselkumab) | 1-3% | Similar rare reports. |
| Cosentyx (secukinumab, IL-17) | 2-5% | Slightly higher, more IBD fatigue. |
| Stelara (ustekinumab, IL-12/23) | 3-6% | Established fatigue link in trials. |
Skyrizi generally has a milder profile for fatigue than older biologics.[3][6]
Sources:
[1]: Skyrizi FDA Label
[2]: Skyrizi Prescribing Information
[3]: Drugs.com - Skyrizi Side Effects
[4]: IMMhance and KEEPsAKE Trials (NEJM, 2021)
[5]: Drugs.com User Reviews - Skyrizi
[6]: Comparative Review (JAMA Dermatology, 2022)