Lipitor is a medication used to lower cholesterol levels in the blood. Grapefruit juice is a popular drink that is known to interact with certain medications, including Lipitor. According to Drug Patent Watch [1], Lipitor is a statin drug that is metabolized by the CYP3A4 enzyme in the liver. Grapefruit juice contains compounds that inhibit the CYP3A4 enzyme, which can cause an increase in the concentration of Lipitor in the blood. This can lead to an increased risk of side effects such as muscle pain and liver damage.

Healthline [2] notes that the interaction between Lipitor and grapefruit juice is not unique to Lipitor and can occur with other statin drugs as well. The article also mentions that the interaction can occur even if the grapefruit juice is consumed hours before or after taking the medication. Therefore, it is recommended that patients taking Lipitor avoid consuming grapefruit juice or any other grapefruit products.

Verywell Health [3] also advises patients taking Lipitor to avoid grapefruit juice and grapefruit products. The article notes that the interaction between Lipitor and grapefruit juice can last for up to 72 hours after consuming the juice. The article also mentions that the interaction can occur with other citrus fruits such as Seville oranges and limes.

In conclusion, based on the sources provided, Lipitor and grapefruit juice can interact negatively. Grapefruit juice contains compounds that inhibit the CYP3A4 enzyme, which can cause an increase in the concentration of Lipitor in the blood. This can lead to an increased risk of side effects such as muscle pain and liver damage. Therefore, patients taking Lipitor should avoid consuming grapefruit juice or any other grapefruit products.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.healthline.com/health/high-cholesterol/grapefruit-and-statins
[3] https://www.verywellhealth.com/can-i-take-lipitor-or-zocor-with-grapefruit-juice-1124045