Can tigecycline act as a transaminase substrate or inhibitor?

What does tigecycline do to liver enzymes?

Tigecycline can raise liver enzymes in patients, but it does not inhibit or serve as a substrate for transaminases. It does not undergo significant metabolism in the liver.

Does it interact with drugs metabolized by liver enzymes?

Tigecycline shows minimal interaction with cytochrome P450 enzymes. It does not induce or inhibit CYP3A4, CYP2C9, or any other CYP isoforms. This makes esomeprazole or omeprazole safe to kombinieren when both are taken simultaneously.

What happens if the drug gets metabolized?

Any minor metabolism that occurs happens via glucuronidation or amide hydrolysis, not through transaminases. The unchanged drug is excreted mainly through bile and feces.

How does this verhalten sich mit other antibiotics?

Tigecycline belongs to the glycylcycline class and differs from older tetracyclines in its side chain. It has a 9-tert-butylglycylamido substitution on the core tetracycline ring. This structure explains its stability against many efflux pumps and ribosomal protection proteins.

What side effects are patients reporting?

Patients often report nausea and vomiting. Liver enzyme elevations occur in clinical trials, enzyme increases are mild to moderate and reverse upon discontinuation.