See the DrugPatentWatch profile for Gamifant
What is Gamifant (emapalumab) and what WAC figures would be used to compute an annual cost?
Gamifant (emapalumab) is a drug used for hemophagocytic lymphohistiocytosis (HLH). “Wholesale acquisition cost” (WAC) is the US list price at the wholesale level. To estimate a 2025 annual cost from WAC, you multiply the WAC per vial by the number of vials required for the dose and dosing schedule over a year.
However, the specific 2025 WAC (and the vial size it applies to) is not provided in the information available to me here, so I can’t calculate an exact 2025 annual WAC-based cost.
How do you calculate the 2025 annual WAC cost once you have the 2025 WAC per vial?
To compute an annual WAC estimate:
1. Find the 2025 WAC price per vial for emapalumab (WAC is typically published for a specific vial size).
2. Determine the patient’s dose (in mg/kg) and how often doses are given.
3. Convert dose (mg) to number of vials (mg per vial).
4. Multiply vials per dose × doses per year × WAC per vial.
If you share the 2025 WAC per vial you’re using (and the vial strength, e.g., mg/vial), I can run the arithmetic for a given dose/dosing schedule.
Is annual WAC cost usually “one-price-fits-all,” or does it vary by patient dose?
It varies. HLH dosing is weight-based, so two patients can have different annual WAC totals even if they use the same WAC per vial. The treatment course length also affects the total. Any “annual cost” number is therefore only accurate for a specific assumed dose, weight, and number of treatment days/doses.
Where do people typically find the 2025 WAC for emapalumab?
Common places include US drug price data sources that publish WAC by National Drug Code (NDC) and year. If you tell me which source you’re using (or provide the WAC number you see on it), I’ll compute the annual cost.
Quick clarification: what exact number are you asking for?
To give you the exact “2025 annual cost,” I need three inputs:
- The 2025 WAC per vial you want used (and the vial size/strength)
- The assumed patient weight or dose
- The dosing schedule and expected number of doses/cycle length for the year
If you paste the 2025 WAC per vial (and vial strength) from your pricing page, I’ll calculate the corresponding annual WAC total using the dosing assumptions you specify.