Lacosamide is an anticonvulsant medication used to treat partial-onset seizures in adults with epilepsy. The question of whether lacosamide causes arrhythmias has been a subject of research and analysis.

According to Drug Patent Watch [1], the prescribing information for lacosamide mentions that the medication may cause cardiac rhythm and conduction disturbances. It is advised to monitor patients for any signs of cardiac abnormalities, especially those with pre-existing cardiac conditions.

A systematic analysis and review of the literature on lacosamide-related arrhythmias was conducted by researchers and published in Cureus [3]. The study analyzed 17 cases of lacosamide-induced arrhythmias reported in the literature. The study found that lacosamide can cause various types of arrhythmias, including bradycardia, atrial fibrillation, and ventricular tachycardia. The study also found that the onset of arrhythmias occurred within a few hours to several days after the initiation of lacosamide therapy.

A study published in the National Center for Biotechnology Information [2] reported a case of a patient who developed severe sinus bradycardia and junctional rhythm after taking lacosamide. The patient had no previous history of cardiac disease or conduction system abnormalities. The study concluded that lacosamide may cause significant cardiac conduction abnormalities and should be used with caution in patients with pre-existing cardiac conditions.

In conclusion, while lacosamide is an effective medication for treating partial-onset seizures, it can cause cardiac rhythm and conduction disturbances. Patients taking lacosamide should be monitored for any signs of cardiac abnormalities, especially those with pre-existing cardiac conditions. Healthcare providers should use caution when prescribing lacosamide to patients with a history of cardiac disease or conduction system abnormalities.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LACOSAMIDE
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790938/
[3] https://www.cureus.com/articles/80198-lacosamide-related-arrhythmias-a-systematic-analysis-and-review-of-the-literature