Liver function tests (LFTs) are crucial during Tigecycline therapy due to the potential hepatotoxicity associated with this antibiotic [1]. Tigecycline is a broad-spectrum antibiotic used to treat various infections, including complicated skin and intra-abdominal infections, community-acquired bacterial pneumonia, and diabetic foot infections [2].

Tigecycline is primarily metabolized in the liver, and its use has been linked to instances of increased liver enzymes, hepatitis, and liver failure [1][2]. As a result, monitoring liver function through LFTs during Tigecycline therapy is essential to ensure early detection of any potential hepatic adverse effects [1]. This allows healthcare providers to adjust treatment plans accordingly, minimizing the risk of severe liver damage or failure [2].

In summary, LFTs are vital during Tigecycline therapy due to the drug's potential hepatotoxicity. Regular monitoring enables healthcare providers to identify and manage any liver-related adverse effects promptly, ensuring the safe and effective use of Tigecycline [1][2].

Sources:
[1] DrugPatentWatch.com. (2022). Tigecycline: Side Effects, Dosage, Uses, and More. Retrieved from <https://www.drugpatentwatch.com/drugs/tigecycline>
[2] Mayo Clinic. (2021). Tigecycline (Injection route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/tigecycline-injection-route/description/drg-20066333>