Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood. According to the NHS [2], Lipitor should be taken once a day, preferably in the evening, with a glass of water. It is important to take Lipitor at the same time every day to maintain a consistent level of the medication in the body. The medication can be taken with or without food, but it is recommended to avoid consuming grapefruit or grapefruit juice while taking Lipitor, as it can increase the risk of side effects.

While the sources do not explicitly state whether Lipitor can be taken without water, it is generally recommended to take medications with water to ensure proper absorption and to prevent irritation of the esophagus. The Everyday Health website [3] advises against crushing, chewing, or breaking Lipitor tablets, as it can affect the medication's effectiveness and increase the risk of side effects. Therefore, it is best to take Lipitor as directed by a healthcare professional, with a glass of water, to ensure its safe and effective use.

Sources:
[2] https://www.nhs.uk/medicines/atorvastatin/how-and-when-to-take-atorvastatin/
[3] https://www.everydayhealth.com/drugs/lipitor
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR