Can antacids affect advil's effectiveness?

What happens if I take antacids and Advil together?

Taking antacids and Advil (ibuprofen) together may affect the effectiveness of Advil, but the impact depends on several factors [1].

How do antacids interact with Advil?

Antacids, such as Tums, Rolaids, or Mylanta, work by neutralizing stomach acid. Ibuprofen, the active ingredient in Advil, has a low solubility in stomach acid. When you take antacids with Advil, the reduced acidity in the stomach can decrease the release of ibuprofen, potentially reducing its effectiveness [1].

Why is this interaction a concern?

This interaction may be more significant for people who experience ulcers or have a history of gastrointestinal bleeding. Aspirin, another NSAID like ibuprofen, has been associated with increased risk of gastrointestinal bleeding, especially when taken with antacids [2].

Alternatives and precautions

If you need to take antacids with Advil, consider the following:

* Take them at different times (e.g., antacids before meals and Advil as directed).
* Choose medications with different mechanisms of action (e.g., acetaminophen for pain relief).
* Consider using a delayed-release ibuprofen formulation, which may be less affected by antacids.

Other considerations

Some antacids, such as aluminum hydroxide, can interfere with the absorption of ibuprofen, while others, like calcium carbonate, may not have a significant impact. Always consult your doctor or pharmacist for personalized advice on taking antacids and Advil together.

Sources:

[1] National Institutes of Health. (2020). Ibuprofen. Retrieved from https://medlineplus.gov/druginfo/meds/a682318.html

[2] World Health Organization. (2017). Aspirin and other nonsteroidal anti-inflammatory drugs. Retrieved from https://www.who.int/news-room/fact-sheets/detail/aspirin-and-other-nonsteroidal-anti-inflammatory-drugs