How does rifampin affect tigecycline's recommended dosage?

How does rifampin change the recommended tigecycline dose?

Rifampin can reduce tigecycline exposure by inducing drug-metabolizing enzymes and transporters. Because of this interaction, tigecycline’s recommended dosage changes when rifampin is given at the same time as tigecycline. The dosing adjustment is to reduce tigecycline to 25% of the usual dose during coadministration with rifampin.

What tigecycline dose do you use when rifampin is coadministered?

During coadministration with rifampin, the usual tigecycline dose is reduced to one-quarter (25%). [1]

Does rifampin affect tigecycline in all patients or only certain scenarios?

The key dosing change is tied to the presence of rifampin. The recommendation is based on rifampin’s ability to lower tigecycline concentrations, so clinicians apply the dosage reduction whenever tigecycline is used concurrently with rifampin. [1]

What happens if rifampin is stopped or started during tigecycline therapy?

If rifampin is started or stopped while a patient is on tigecycline, the dosing recommendation is determined by whether rifampin and tigecycline are being coadministered at that time. That means the tigecycline dose should follow the 25% reduction during the period of coadministration. [1]

Source

1. DrugBank drug interaction note: rifampin and tigecycline (includes the 25% dose reduction recommendation during coadministration): https://go.drugbank.com/drugs/DB01223