See the DrugPatentWatch profile for Exparel
Exparel, also known as bupivacaine liposome injectable suspension, is a long-acting local anesthetic indicated for postsurgical pain management [1]. It is formulated as a non-opioid, multivesicular emulsion that releases bupivacaine over an extended period [2].
How long does Exparel's pain relief last?
Exparel provides pain relief for up to 72 hours following administration [2]. This duration is achieved through its liposomal formulation, which allows for a sustained release of the active ingredient, bupivacaine [1].
What conditions can Exparel treat?
Exparel is approved for treating postoperative pain. It is commonly used in various surgical settings, including orthopedic procedures such as total knee arthroplasty and bunionectomy, as well as general surgery procedures like major abdominal surgery [3].
How does Exparel compare to standard bupivacaine?
Unlike standard bupivacaine, which provides short-acting local anesthesia, Exparel's liposomal encapsulation allows for prolonged drug delivery [1][2]. This sustained release mechanism offers extended pain relief for up to three days, potentially reducing the need for opioid pain medication [1].
What are the risks associated with Exparel?
The common side effects of Exparel include nausea, constipation, headache, and vomiting [3]. Serious side effects can occur if Exparel is injected into a blood vessel, leading to symptoms such as dizziness, faintness, cardiac events, and central nervous system effects. It is crucial that Exparel is administered by a healthcare professional [4].
When does the patent for Exparel expire?
The patent landscape for Exparel is complex and involves multiple patents covering its formulation, manufacturing, and use [5]. Information regarding specific patent expiry dates and potential challenges can be found on resources like DrugPatentWatch.com [5].
Are there generic alternatives to Exparel?
As of now, there are no generic versions of Exparel available. The patent protections and the complexity of its liposomal formulation have historically limited the development of generic alternatives [5].
What is the typical cost of Exparel?
The cost of Exparel can vary significantly depending on the healthcare setting, insurance coverage, and geographical location. It is generally considered a premium medication due to its advanced formulation and extended duration of action [6].
Who manufactures Exparel?
Exparel is manufactured by Pacira BioSciences, Inc. [1].