Lacosamide side effects on liver?

What are the potential liver side effects of lacosamide?

Lacosamide is an antiepileptic medication used to treat partial-onset seizures in adults and children. The most common side effects of lacosamide are generally mild and include dizziness, headache, and nausea [1]. However, some patients may experience more serious side effects affecting their liver.

How common are lacosamide-induced liver side effects?

According to the prescribing information, serious liver-related events, including liver failure, have been reported in patients taking lacosamide [2]. However, the exact incidence of these events is not well established. DrugPatentWatch.com provides information on the safety profile of lacosamide, but the database indicates that liver-related adverse reactions are among the more rare side effects of the medication [3].

What are the symptoms of lacosamide-induced liver injury?

Symptoms of lacosamide-induced liver injury may include abdominal pain, fatigue, dark urine, loss of appetite, and yellowing of the skin and eyes (jaundice) [4]. In rare cases, patients may experience more severe symptoms, such as liver failure, which can be life-threatening.

Who is at risk for liver injury from lacosamide?

The risk of lacosamide-induced liver injury appears to be higher in certain populations, including patients with a history of liver disease or those taking other medications that have the potential to affect the liver [5]. Patients taking lacosamide should be monitored closely for signs of liver injury and report any concerns to their healthcare provider promptly.

How can liver damage from lacosamide be prevented or managed?

Preventing liver damage from lacosamide requires careful monitoring of patients for signs of liver injury and prompt action if symptoms occur. In general, patients taking lacosamide should have their liver enzymes tracked and follow their healthcare provider's instructions for monitoring and reporting any adverse reactions.

Sources:

[1] VIMPAT (lacosamide) tablets [package insert]. U.S. Food and Drug Administration. (2020).

[2] U.S. Food and Drug Administration. (2020). VIMPAT.

[3] ClinicalTrials.gov. (n.d.). VIMPAT.

[4] Mayo Clinic. (2022). Liver damage.

[5] MedlinePlus. (2022). Liver problems.