Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood. It works by blocking an enzyme that produces cholesterol in the liver [1]. According to the sources provided, there is no evidence to suggest that Lipitor interacts with low-fat substitutes. However, it is important to note that consuming low-fat substitutes alone may not be enough to lower cholesterol levels, and they should be used in conjunction with a healthy diet and exercise regimen [2][3].

In terms of alternatives to statins, the sources suggest that there are several options available, including plant sterols and stanols, niacin, fibrates, and bile acid sequestrants. These alternatives may be used alone or in combination with each other or with statins, depending on the individual's cholesterol levels and medical history [2][3].

It is important to consult with a healthcare provider before making any changes to medication or diet, as they can provide personalized recommendations based on individual needs and medical history.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.healthline.com/health/high-cholesterol/alternatives-statins
[3] https://www.webmd.com/cholesterol-management/features/are-there-statin-alternatives