Lyrica, also known as pregabalin, is a medication used to treat epilepsy, fibromyalgia, and nerve pain. While generally well-tolerated, Lyrica can cause several cardiovascular side effects, particularly at higher doses or when combined with other medications.
According to the Lyrica prescribing information [1], some common cardiovascular side effects associated with Lyrica include:
- Edema, or swelling, which is reported in up to 14% of patients taking the medication [1]. Edema can be a sign of fluid retention and is often more likely to occur in patients with pre-existing heart or kidney conditions.
- Weight gain is another common side effect, reported in up to 10% of patients [1]. Weight gain can be a result of increased appetite or fluid retention.
- Orthostatic hypotension, or dizziness caused by a sudden drop in blood pressure, has been reported in some patients [2]. This is more likely to occur when standing up quickly from a lying or sitting position.
- Tachycardia, or an increased heart rate, has been reported in some patients taking Lyrica [3]. Tachycardia is often more likely to occur at higher doses or in patients with pre-existing heart conditions.
It is essential to note that these side effects can often be managed with lifestyle changes, such as maintaining a healthy diet, exercising regularly, and getting enough sleep. Additionally, patients taking Lyrica should inform their healthcare provider of any pre-existing heart or kidney conditions, as well as any medications they are currently taking, to minimize the risk of cardiovascular side effects.
For more information on Lyrica side effects, visit:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265550/
Sources:
[1] Lyrica (pregabalin) prescribing information. Pfizer Inc.
[2] FDA. (2020). Lyrica (pregabalin) FDA Label Change. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021364s027lbl.pdf
[3] Pregabalin (Lyrica): side effects, uses, dosage, interactions, and warnings [www.medicinenet.com]
4 https://drugpatentwatch.com