Can patients on Cosentyx (secukinumab) get live vaccines?
Cosentyx (secukinumab) is an anti–IL-17A biologic that can affect immune responses. Live vaccines are generally avoided in people taking immunomodulating biologics like Cosentyx. The recommended approach is to use non-live (inactivated) vaccines instead, unless your clinician specifically advises otherwise for a particular situation [1].
What about shingles (live) and other specific live vaccines?
A common concern is shingles vaccination. The live zoster vaccine (the older formulation) should not be used in patients taking biologic immune-modulating therapy such as Cosentyx [1]. Instead, vaccination plans usually focus on non-live shingles vaccines where available and appropriate based on local guidance [1].
Other live vaccines that are typically avoided on immunomodulators include live attenuated influenza (nasal spray) and other live travel or childhood vaccines, depending on the product and country schedules [1].
How long should you wait before/after starting Cosentyx?
The general principle with live vaccines is timing around immunosuppression: live vaccines should be given before starting therapy (when feasible) or avoided during treatment. Your prescriber can recommend an appropriate schedule based on your dosing and immune status [1].
What if someone already got a live vaccine while on Cosentyx?
If a live vaccine is accidentally given while on Cosentyx, contact the prescribing clinician promptly for individualized advice on next steps and monitoring. Recommendations can vary depending on dose timing and the specific vaccine [1].
Are non-live vaccines safe with Cosentyx?
Non-live (inactivated or otherwise non-replicating) vaccines are generally preferred and can usually be given while on Cosentyx, but you should confirm the plan with your clinician or pharmacist to match your schedule and medical history [1].
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Sources
[1] Cosentyx prescribing information (secukinumab) – vaccine guidance (live vaccines). https://www.cosentyx.com/prescribing-information