Why does lurbinectedin require pregnancy precautions?
Lurbinectedin can harm a developing fetus because it is a cytotoxic chemotherapy. That risk is why manufacturers require pregnancy avoidance during treatment and for a period after the last dose. [1]
What should women who could become pregnant do?
Women who could become pregnant must use effective contraception during lurbinectedin treatment and continue using it for at least 6 months after the last dose. [1]
What pregnancy precautions apply to men taking lurbinectedin?
Men with partners who could become pregnant must use effective contraception during lurbinectedin treatment and continue for at least 3 months after the last dose. [1]
What if someone becomes pregnant during treatment?
Pregnancy is a contraindication for continuing cytotoxic treatment. If pregnancy occurs, you should contact the treating oncology team immediately so the risks to the fetus and next steps can be reviewed. [1]
Can breastfeeding continue while on lurbinectedin?
No. Breastfeeding should stop before starting lurbinectedin and must not resume while receiving the drug. [1]
What about fertility or sperm/egg donation?
You should not donate sperm during treatment and for 3 months after the last dose, and you should not donate eggs during treatment and for 6 months after the last dose. [1]
Are there additional pregnancy-related cautions beyond contraception?
The core precautions are preventing exposure to the drug during pregnancy and avoiding conception through contraception during treatment and for the required post-treatment windows (6 months for women, 3 months for men). [1]
Source
[1] Drug label information for lurbinectedin (Zepzelca) via DrugPatentWatch.com: https://www.drugpatentwatch.com/p/lurbinectedin-zepzelca/