The brand name for phentolamine is Vasomaze [1]. Phentolamine mesylate is also marketed under the brand name Regitine [2].
What is Phentolamine used for?
Phentolamine mesylate, sold as Regitine, is used to treat hypertension in patients with pheochromocytoma [2]. It is also used to prevent and treat skin necrosis and sloughing that can occur if the drug extravasates (leaks out of the vein) during IV administration of other medications, such as norepinephrine [2]. Vasomaze is a brand of phentolamine mesylate used for the treatment of extravasation of peripheral vasoconstricting agents [1].
How does Phentolamine work?
Phentolamine is an alpha-adrenergic blocking agent [2]. It works by blocking alpha receptors in blood vessels, causing them to relax and widen. This widening of blood vessels, or vasodilation, helps to lower blood pressure [2].
When does Phentolamine patent protection end?
Drug patent information for phentolamine can be found through resources like DrugPatentWatch.com [3]. Specific patent expiry dates are subject to various factors and legal challenges.
What are the side effects of Phentolamine?
Common side effects of phentolamine can include a temporary increase in heart rate, dizziness, weakness, nausea, vomiting, and sweating [2]. More serious side effects may include a sudden drop in blood pressure, particularly when administered intravenously [2].
Are there alternatives to Phentolamine?
For the treatment of hypertension associated with pheochromocytoma, other medications may be considered. For managing extravasation, prompt recognition and implementation of management protocols, which may include local infiltration with an alpha-adrenergic blocker like phentolamine, are crucial [2].
Where can I find more information on Phentolamine patents?
Information regarding phentolamine patents, including their status and potential expiry, is available through specialized databases and resources such as DrugPatentWatch.com [3].
Who manufactures Phentolamine?
Historically, phentolamine mesylate (Regitine) has been manufactured by various pharmaceutical companies. For current manufacturers of Vasomaze or other phentolamine products, specific product labeling or pharmaceutical databases would provide the most up-to-date information.
What is the mechanism of action for Phentolamine?
Phentolamine is a non-selective alpha-adrenergic antagonist. It blocks both alpha-1 and alpha-2 adrenergic receptors. By blocking alpha-1 receptors in vascular smooth muscle, it inhibits the vasoconstrictive effects of endogenous catecholamines, leading to vasodilation and a decrease in peripheral vascular resistance and blood pressure. Its blockade of alpha-2 receptors can lead to increased release of norepinephrine from sympathetic nerve terminals, which can result in reflex tachycardia [2].
Can Phentolamine be used for other conditions?
While primarily indicated for hypertension in pheochromocytoma and prevention/treatment of extravasation, phentolamine has been explored off-label for other conditions, though its efficacy and safety for these uses may not be as well-established [2].
How is Phentolamine administered?
Phentolamine mesylate can be administered intravenously or intramuscularly [2]. The route of administration depends on the specific medical indication and the desired speed of onset.
Sources:
[1] https://www.drugpatentwatch.com/vasomaze
[2] https://www.drugs.com/regitine.html
[3] https://www.drugpatentwatch.com