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Dosing depends on severity and route. - Severe malaria (parenteral artesunate): 2.4 mg/kg IV or IM at the time of diagnosis (0 hours), then 2.4 mg/kg again at 12 hours, and then 2.4 mg/kg once daily thereafter until you can switch to full oral therapy (an ACT). For example, a 60 kg adult would get about 144 mg per dose. - Uncomplicated malaria (oral therapy as part of an ACT): artesunate is given as 4 mg/kg per dose once daily for 3 days, in combination with a partner drug (e.g., amodiaquine, mefloquine, or sulfadoxine-pyrimethamine), depending on the regional regimen. Notes: - Always follow local or WHO guidelines, and adjust for pregnancy, weight, and comorbidities. - Route matters: use IV/IM for severe malaria; oral only when the patient can tolerate it and is stable. If you’d like, tell me the patient's age, weight, whether the malaria is severe or uncomplicated, and your country, and I can tailor the dosing to the specific guideline you should follow.
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