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Atomoxetine ingredients?

See the DrugPatentWatch profile for Atomoxetine

Atomoxetine (commonly sold as Strattera®) is a non‑stimulant medication used mainly to treat attention‑deficit/hyperactivity disorder (ADHD).
Below is a rundown of the active ingredient and the typical inactive ingredients (excipients) you’ll find in the most common dosage forms. Keep in mind that excipient lists can vary slightly between manufacturers, lot numbers, and formulations (tablet vs. oral solution), so always check the package insert or talk to your pharmacist for the exact composition of your specific product.


1. Active Ingredient

  • Atomoxetine hydrochloride
    • Dose strength: 10 mg, 18 mg, 25 mg, 40 mg, 60 mg, 80 mg, 100 mg (tablet); 0.25 mg mL⁻¹, 0.5 mg mL⁻¹ (oral solution)

2. Typical Inactive Ingredients (Excipients)

Form Excipients (generic names) Role/Notes
Tablet (Strattera®) Microcrystalline cellulose (filler)
Croscarmellose sodium (disintegrant)
Mannitol (sweetener & filler)
Magnesium stearate (lubricant)
Silicon dioxide (anti‑caking agent)
Polyethylene glycol 6000 (plasticizer)
Titanium dioxide (whitening pigment)
FD&C Red No. 40 (color)
Fluorinated parabens (preservative)
Oral Solution (Strattera® liquid) Water (solvent)
Sodium citrate (pH adjuster)
Sodium benzoate (preservative)
Polyethylene glycol 400 (solubilizer)
Maltitol (sweetener)
Natural and artificial flavors (taste)
Citric acid (flavor/acidifier)
Sodium chloride (taste & stability)
Glycerin (humectant)
Caramel color (appearance)
Tetrasodium EDTA (stabilizer)
Sodium hydroxide (pH adjuster)

Note: The exact excipients and their quantities may differ slightly depending on the manufacturer’s formulation, the specific strength, and whether the product is a tablet or a liquid.


3. Common Brand Variants & Their Excipients

Brand Form Typical Inactive Ingredients (select highlights)
Strattera® (Pfizer) Tablet microcrystalline cellulose, croscarmellose sodium, mannitol, magnesium stearate, titanium dioxide, FD&C Red No. 40
Oral Solution water, sodium citrate, sodium benzoate, polyethylene glycol 400, maltitol, sodium chloride
Strattera® (Other manufacturers) Tablet may use different disintegrants (e.g., sodium starch glycolate) or lubricants (e.g., stearic acid) but similar filler list
Strattera® (Generic) Tablet usually the same core excipients; sometimes “microcrystalline cellulose” is replaced with “cellulose powder”
Oral Solution similar to brand‑name but may use natural flavors instead of artificial ones

4. Things to Watch For

  • Allergies / Sensitivities: If you’re allergic to any of the common excipients (e.g., titanium dioxide, parabens, sodium benzoate, artificial dyes), let your pharmacist know.
  • Drug‑Drug Interactions: Atomoxetine itself interacts mainly with CYP2D6 inhibitors/inducers; excipients generally do not affect metabolism.
  • Kidney/Heart Function: No excipient in typical formulations is a major renal or cardiac hazard, but always double‑check if you have a specific medical condition.
  • Children & Pregnant Women: Follow prescribing instructions; the oral solution is often preferred in pediatrics due to easier dosing.

5. Quick Reference for Common Excipients

Excipients Possible Sensitivities / Concerns
Titanium dioxide Rare but may cause respiratory irritation in very fine dust forms; negligible in tablets.
FD&C Red No. 40 Colorant; rare allergic reactions.
Sodium benzoate Preservative; may cause headaches or skin irritation in sensitive individuals.
Mannitol Sweetener; can cause mild gastrointestinal upset in large amounts.
PEG 400 / PEG 6000 Solvent/lubricant; usually well tolerated.
Fluorinated parabens Preservatives; generally safe at low concentrations.

Bottom Line

Atomoxetine’s core drug is atomoxetine hydrochloride. The surrounding excipients—filler, disintegrant, lubricant, colorants, preservatives, and sweeteners—are chosen to make the tablet dissolve correctly, taste acceptable (in the liquid), and stay stable. If you have any concerns about a specific ingredient or potential allergens, bring up the list with your pharmacist or physician.



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