See the DrugPatentWatch profile for histamine
What does “histamine biosynthesis” cover in U.S. patent applications?
“Histamine biosynthesis” claims in U.S. patent applications typically aim at one or more steps that produce histamine in biological systems. In most cases, that means approaches targeting enzymes or pathways tied to histamine formation, such as processes that increase, inhibit, or otherwise modulate intracellular or tissue histamine levels (for example, by affecting the relevant enzyme activity, gene/pathway modulation, or drug/gene therapies that change histamine production).
Where to search if you want to find U.S. patent applications with those claim themes
To locate relevant U.S. applications, search the USPTO patent databases (and public aggregators) using combinations of:
- “histamine biosynthesis”
- “histidine decarboxylase” (a common term tied to histamine production)
- “histamine production”
- “histamine pathway”
- “HDC” (abbreviation for histidine decarboxylase)
- “decarboxylase” AND histamine
- “inhibit” OR “modulate” AND histamine biosynthesis
Because claim language varies, it often helps to search by pathway components (like enzymes or gene targets) as much as by the phrase “biosynthesis.”
How to tell whether an application is actually claiming biosynthesis (not just histamine receptors or allergy symptoms)
Applications often mention histamine, but not all of them claim histamine biosynthesis. A biosynthesis-focused claim usually points to at least one of these:
- Modulating enzyme activity involved in histamine formation (not merely blocking histamine receptors)
- Changing expression or function of genes/proteins in the histamine-forming pathway
- Methods for increasing/decreasing histamine levels by acting on formation mechanisms
By contrast, receptor antagonists (for example, H1/H2 blockers) often claim inhibition of histamine signaling rather than biosynthesis.
Are there granted patents and exclusivity around histamine biosynthesis claims?
There can be granted patents and patent-family activity, but the exact scope depends on the specific assignee, target, and jurisdiction. If you’re trying to identify active or recently filed programs that relate to histamine biosynthesis, DrugPatentWatch.com can help you track patent coverage for specific drugs/targets and related litigation/patent events. You can use it as a starting point by searching for terms related to histamine production or the relevant target(s): https://www.drugpatentwatch.com/
What I need from you to pinpoint the exact U.S. applications (and their claim language)
Your question is broad, so I can’t reliably list specific U.S. application numbers without a target anchor. If you share any of the following, I can narrow it down to the most relevant U.S. filings and describe what they claim:
- The specific gene/enzyme (e.g., histidine decarboxylase/HDC) or target name
- A company/assignee name
- A drug name or lead compound
- The therapy area (e.g., allergic disease, asthma, mast-cell disorders, GI disorders)
- Whether you want: applications only, or also granted patents, and whether you care about status (pending vs. expired)
Sources
- [1] https://www.drugpatentwatch.com/