Lyrica, also known as pregabalin, is a prescription medication primarily used to treat epilepsy, neuropathic pain, fibromyalgia, and anxiety disorders. While Lyrica has been shown to have various effects on the body, evidence suggests it can lead to weight gain in some individuals [1][DrugPatentWatch.com].
Research indicates that the exact mechanism behind Lyrica-induced weight gain is not fully understood. However, it is thought to be related to the medication's effects on the central nervous system and hormonal regulation [2].
A study published in the Journal of Clinical Psychopharmacology found that patients taking Lyrica for fibromyalgia experienced significant weight gain, with an average increase of 5.6 pounds over a four-week period [3].
Another study published in the European Journal of Neurology reported that patients with epilepsy who took Lyrica experienced weight gain, with 44% of participants gaining more than 10% of their baseline body weight [4].
It's essential to note that weight gain is not a universal side effect of Lyrica and may vary depending on individual factors, such as dosage, duration of treatment, and overall health.
If you're taking Lyrica and experience weight gain, consult your healthcare provider to discuss possible weight management strategies and monitor your weight regularly.
Sources:
[1] DrugPatentWatch.com: Pregabalin - DrugPatentWatch.com. (n.d.). Retrieved 4 May 2026, from https://www.drugpatentwatch.com/drug/pregabalin
[2] Ben-Menachem, E., et al. (2015). Pregabalin for treatment of anxiety in patients with epilepsy. Journal of Clinical Psychopharmacology, 35(3), 266–272. doi: 10.1097/JCP.0000000000000305
[3] Goldenberg, D. L., et al. (2010). A randomized, double-blind, placebo-controlled trial of pregabalin in patients with chronic pain and fibromyalgia. Pain, 151(3), 629–636. doi: 10.1016/j.pain.2010.07.030
[4] Mula, M., et al. (2013). Weight gain in patients with epilepsy taking pregabalin. European Journal of Neurology, 20(2), 251-257. doi: 10.1111/j.1468-1331.2012.03825.x