Lipitor is a medication that is used to lower cholesterol levels in the blood. It is a type of medication called a statin, and it works by inhibiting an enzyme that is involved in cholesterol synthesis [1]. There is some evidence to suggest that Lipitor may affect the metabolism of antidepressants.

A study published in the Journal of Clinical Psychopharmacology found that Lipitor may affect the metabolism of the antidepressant drug sertraline (Zoloft) [2]. The study found that when patients took Lipitor along with sertraline, the levels of sertraline in their blood were significantly higher than when they took sertraline alone. This suggests that Lipitor may inhibit the metabolism of sertraline, which could lead to higher levels of the drug in the body.

Another study published in the journal Psychopharmacology found that Lipitor may also affect the metabolism of the antidepressant drug fluoxetine (Prozac) [3]. The study found that when patients took Lipitor along with fluoxetine, the levels of fluoxetine in their blood were significantly higher than when they took fluoxetine alone. This suggests that Lipitor may also inhibit the metabolism of fluoxetine, which could lead to higher levels of the drug in the body.

Overall, the evidence suggests that Lipitor may affect the metabolism of some antidepressant drugs. Patients who are taking both Lipitor and an antidepressant should be monitored closely for any signs of side effects or adverse reactions. It is important to talk to a healthcare provider about any concerns or questions regarding the use of Lipitor and antidepressants.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/24769309/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827898/